gtp cyclohydrolase ii การใช้

• "' 2, 5-diamino-6-hydroxy-4-( 5-phosphoribosylamino ) pyrimidine "'is a metabolite in the purine metabolism, formed by the hydrolysis of GTP by GTP cyclohydrolase II . Alternatively two separate enzymes can carry out this reaction, initially GTP cyclohydrolase IIa hydrolyses the 8, 9 bond to form 2-Amino-5-formylamino-6-( 5-phospho-D-ribosylamino ) pyrimidin-4 ( 3H )-one, followed by de-formylation by 2-amino-5-formylamino-6-ribosylaminopyrimidin-4 ( 3H )-one 5'- monophosphate deformylase . 2, 5-diamino-6-hydroxy-4-( 5-phosphoribosylamino ) pyrimidine is deaminated by Diaminohydroxyphosphoribosylaminopyrimidine deaminase to form 5-amino-6-( 5-phosphoribosylamino ) uracil.